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Table 2. Diagnosis of Thyroid Disease
• Complete Basic Profile - T4, T3, FT4, FT3, T4AA, T3AA)
• Additional Tests - TSH, TgAA
• Older Tests (T4, T4 + T3)
Serum T4 and/or T3 alone are not reliable for diagnosis because:
– overdiagnose hypothyroidism
– underdiagnose hyperthyroidism
– fail to detect early compensatory disease and thyroiditis
– influenced by nonthyroidal illness and certain drugs
• Newer Tests
Free (Unbound) T4
Less likely to be influenced by nonthyroidal illness or drugs
Valid
– equilibrium dialysis
– solid-phase analog RIA
– chemiluminescence solid-phase
Less reliable - liquid-phase analog RIA
Endogenous Canine TSH
In primary hypothyroidism, as free T4 levels fall, pituitary output of TSH rises
– elevated TSH usually indicates primary thyroid disease
– 20-40% discordancy observed between expected and actual findings
– published normal ranges may need revising upwards
– affected by concomitant chronic renal disease

Canine TgAA
Thyroglobulin autoantibodies are present in serum of cases with lymphocytic thyroiditis.
– positive results confirm diagnosis ; 8% false negative
– 20-40% of cases have circulating T3 and/or T4AA
– allows for early diagnosis and genetic counseling